منابع مشابه
Recent Insights into the Pathogenesis of Type AA Amyloidosis
The amyloidoses are a group of life-threatening diseases in which fibrils made of misfolded proteins are deposited in organs and tissues. The fibrils are stable, insoluble aggregates of precursor proteins that have adopted an antiparallel beta-sheet structure. In type AA, or reactive, amyloidosis, the precursor protein of the fibrils is serum amyloid A (SAA). SAA is a 104-amino-acid protein tha...
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F or endemic dimorphic fungi, switching between different morphologies is crucial for pathogenesis. These ascomycetes, which include Blastomyces dermatitidis, Histoplasma capsulatum, Coccidioides immitis, Coccidioides posadasii, Paracoccidioides brasiliensis, Sporothrix schenckii, and Penicillium marneffei, grow as mycelia that produce conidia or, in the case of Coccidioides spp., arthroconidia...
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Glaucoma is a neurodegenerative disease of the optic nerve characterized by progressive loss of retinal ganglion cells (RGCs), which can lead to irreversible blindness. Numerous factors have been implicated in the disease, with high intraocular pressure (IOP), coupled with advanced age, being major risk factors. Other factors include ischemia, generation of reactive oxygen species, a genetic pr...
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Viral lower respiratory tract infection (LRTI) can lead to severe disease at all ages, but with the exception of influenza vaccination, prevention is not available for most respiratory viruses, hence, effective, disease-limiting therapy is urgently required. To enable the development of novel effective therapeutic approaches, we need to improve understanding of the pathological mechanisms of vi...
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Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour ...
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2017-03-771493